What is ADVATE?
ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called “classic” hemophilia). ADVATE is used to prevent and control bleeding in adults and children (0-16 years) with hemophilia A. Your healthcare provider (HCP) may give you ADVATE when you have surgery. ADVATE can reduce the number of bleeding episodes in adults and children (0-16 years) when used regularly (prophylaxis). ADVATE is not used to treat von Willebrand disease.1
Preventing bleeds is key
Prophylaxis treatment may help you prevent or reduce bleeds. ADVATE is a prophylaxis treatment for people with hemophilia A.1
study design1
In an 18-month study, 53 people with severe to moderately severe hemophilia A took ADVATE on-demand for the first 6 months and then were switched at random to 1 of 2 ADVATE prophylactic dosing regimens for an additional 12 months. The number and type of bleeds experienced were tracked for the length of the study.
bleed reduction DATA
In a study of 53 patients who switched from on-demand to prophylaxis treatment, ADVATE prophylaxis reduced bleeds.1
What are ABR and AJBR?
Annualized bleed rate (ABR) and annualized joint bleed rate (AJBR) are common terms/abbreviations used when talking about the average number of bleeds a person with a bleeding disorder experiences in a year.2 Median ABR or AJBR refers to the middle value in a sorted list of annual bleed rates.
study design1
In an 18-month study, 53 people with severe to moderately severe hemophilia A took ADVATE on-demand for the first 6 months and then were switched at random to 1 of 2 ADVATE prophylactic dosing regimens for an additional 12 months. The number and type of bleeds experienced were tracked for the length of the study.
Selected Important Risk Information
What should I tell my HCP before using ADVATE?
Tell your HCP if you:
- Have or have had any medical problems.
- Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
- Have any allergies, including allergies to mice or hamsters.
- Are breastfeeding. It is not known if ADVATE passes into your milk and if it can harm your baby.
- Are or become pregnant. It is not known if ADVATE may harm your unborn baby.
- Have been told that you have inhibitors to factor VIII (because ADVATE may not work for you)
Please see Detailed Important Risk Information below.
study design1
In an 18-month study, 53 people with severe to moderately severe hemophilia A took ADVATE on-demand for the first 6 months and then were switched at random to 1 of 2 ADVATE prophylactic dosing regimens for an additional 12 months. The number and type of bleeds experienced were tracked for the length of the study.
bleed prevention DATA
In a study of 53 patients who switched from on-demand to prophylaxis treatment, ADVATE prophylaxis significantly reduced bleeds.1
What is prophylaxis, or “prophy”?
Prophylaxis treatment is taken regularly to prevent bleeds rather than waiting for a bleed to happen and treating it on-demand.1
study design1
In an 18-month study, 53 people with severe to moderately severe hemophilia A took ADVATE on-demand for the first 6 months and then were switched at random to 1 of 2 ADVATE prophylactic dosing regimens for an additional 12 months. The number and type of bleeds experienced were tracked for the length of the study.
Selected Important Risk Information
What important information do I need to know about ADVATE?
- You can have an allergic reaction to ADVATE. Call your HCP right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
- Do not attempt to infuse yourself with ADVATE unless you have been taught by your HCP or hemophilia center.
Please see Detailed Important Risk Information below.
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