Unlocking Self-Potential

Broad Selection of Doses

ADVATE [Antihemophilic Factor (Recombinant)]:
Customized convenience with 2 mL or 5 mL diluent volume

  • Flexibility:
    • 11 potencies provide more options for single-vial infusions—more than any other FVIII product*1
    • 7 different potencies available with 2 mL diluent volume, up to 1700 IU
    • 4 different potencies available with 5 mL diluent volume, from 2000 IU to 4000 IU
  • Convenience: 60% reduction of infusion volume with 2 mL diluent1
  • Simplicity: Easy mixing steps with the ADVATE with BAXJECT III Reconstitution System

Only ADVATE has this range of opportunities for single-vial dosing options.

*From an open-label, randomized crossover study, comparing pharmacokinetics and safety.

ADVATE and the diluent come prepackaged in the BAXJECT III reconstitution system.

Infusion Information for ADVATE

You should be trained on how to do infusions by your hemophilia treatment center or your healthcare provider. The maximum infusion rate is 10 mL/min.

Selected Important Risk Information for ADVATE

Your healthcare provider will tell you how much ADVATE to use based on your weight, the severity of your hemophilia A, and where you are bleeding. You may have to have blood tests done after getting ADVATE to be sure that your blood level of factor VIII is high enough to clot your blood.

Find Your Single Vial Dose

The ADVATE Single Vial Dose Finder is designed to show you what single-vial dosing options for ADVATE are available at any time.

Please note that the displayed vial is for demonstation purposes only and the actual vial will be provided from the closest dosing option available.

Step 1 of 3

  • Step 1
  • Step 2
  • Step 3

Return to Step 1

I want to find a single vial dose for my/my child’s prescription.

Enter your/your child’s prescribed dose of ADVATE.

Submit

Please complete all fields.

Return to Step 2

Vial Finder Results
IU

As of DATE, Shire has YYYY IU single-dose vial of ADVATE available in inventory.

Based on your/your child’s prescription, this is the closest single vial dose opportunity currently available.

Connect with a Shire Representative to find out how your factor provider can order your ADVATE prescription in a single vial.

Connect with your local Shire Representative

Based on your/your child’s prescription, there is no ADVATE single vial dose opportunity available at this time.

Connect with a Shire representative to find out how your factor provider can order your ADVATE prescription in multiple vials, or in a single vial, when a single vial option becomes available in your prescription.

Connect with your local Shire Representative

I want to find a
single vial dose
for my/my child’s
prescription.

I don’t know
my/my child’s
prescription.*

Return to Step 1

I want to find a single vial for my/my child’s weight and prescribed % factor correction.*

Enter your/your child’s weight in pounds (lb) or kilograms (kg).

Choose your/your child’s prescribed % factor correction.

You must know your/your child’s % factor correction in order to use this Single Vial Dose Finder. Please consult your physician or HTC if you do not know you/your child’s appropriate % factor correction.

What’s this?

Factor correction is the desired increase in factor VIII level as a % of the normal factor VIII level for people who do not have hemophilia A. The “normal” factor level for people who do not have hemophilia A is 100%.

If you do not know the factor correction level that is used for your prescribed dose, you should consult your physician.

Return to Step 2

Submit

Please complete all fields.

Return to Step 2

Vial Finder Results

As of DATE, Shire has a YYYY IU single-dose vial of ADVATE available in inventory.

Based on your/your child’s weight and % factor correction, this is the closest single vial dose opportunity currently available.

Connect with a Shire Representative to find out how your factor provider can order your ADVATE prescription in a single vial.

Connect with your local Shire Representative

Based on your/your child’s weight and % factor correction, there is no ADVATE single vial dose opportunity available at this time.

Connect with a Shire Representative to find out how your factor provider can order your ADVATE prescription in multiple vials, or in a single vial, when a single vial option becomes available in your prescription.

Connect with your local Shire Representative

* The Single Vial Dose Finder is intended only for finding a single-vial option for you/your child. It is not meant to be used for dosing recommendations. Proper dosing regimens must be discussed with and prescribed by your physician.

Indications and Detailed Important Risk Information for ADVATE [Antihemophilic Factor (Recombinant)].
See full Prescribing Information.

ADVATE [Antihemophilic Factor (Recombinant)] Important Information

Indications

ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called "classic" hemophilia).
ADVATE is used to prevent and control bleeding in adults and children (0-16 years) with hemophilia A.
Your healthcare provider may give you ADVATE when you have surgery.
ADVATE can reduce the number of bleeding episodes in adults and children (0-16 years) when used regularly (prophylaxis).

ADVATE is not used to treat von Willebrand disease.

DETAILED IMPORTANT RISK INFORMATION

You should not use ADVATE if you:

  • Are allergic to mice or hamsters.
  • Are allergic to any ingredients in ADVATE.

Tell your healthcare provider if you are pregnant or breastfeeding because ADVATE may not be right for you.

You should tell your healthcare provider if you:

  • Have or have had any medical problems.
  • Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
  • Have any allergies, including allergies to mice or hamsters.
  • Have been told that you have inhibitors to factor VIII (because ADVATE may not work for you).

Your body may form inhibitors to factor VIII. An inhibitor is part of the body's normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.

You can have an allergic reaction to ADVATE.

Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Side effects that have been reported with ADVATE include: cough, headache, joint swelling/aching, sore throat, fever, itching, dizziness, hematoma, abdominal pain, hot flashes, swelling of legs, diarrhea, chills, runny nose/congestion, nausea/vomiting, sweating, and rash.

Tell your healthcare provider about any side effects that bother you or do not go away or if your bleeding does not stop after taking ADVATE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see ADVATE full Prescribing Information.