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The ADVATE Choice

Today, people know hemophilia may be part of their life but it doesn’t have to define it.

Whether you’re building your career, raising a family, or pursuing other goals, ADVATE therapy was developed with your lifestyle in mind.

Independence

Portable, easy to use, and a fit for active lives, ADVATE provides the broadest selection of dosage strengths.4,7,9,14-17 Learn more.

Confidence

Proven to manage most bleeds with a single infusion in previously treated patients (PTPs)a and ADVATE has more than 6 years of experience.4-6 Learn more.

a In the pivotal study, 93% of bleeds were managed with 1 or 2 infusions.4

Assurance

Processed with no blood-based additives, ADVATE eliminates the potential risk of pathogens that may be carried by blood-based additivesb, because no plasma proteins are added at any stage of processing.2-4 Learn more.

b There have been no confirmed reports of viral transmissions with recombinant factor VIII therapies.

There for You

Through therapies, participation, and progress, Baxter is there for you with an ongoing commitment to the hemophilia community. Learn more.

Could ADVATE be right for you? Choosing your factor VIII therapy is an individual choice. Read the My Choice Stories of people who use ADVATE to control their bleeding disorder and talk to your doctor.

 

Freedom of Choice: Get 6 Free doses of ADVATE when you enroll in the Freedom of Choice program

Sign up now

ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method] is a medicine used to replace clotting factor VIII that is missing in people with hemophilia A. ADVATE is used to prevent and control bleeding in people with hemophilia A. Your doctor may give you ADVATE when you have surgery.

ADVATE is not used to treat von Willebrand's Disease.

>Important Risk Information for ADVATE therapy

You should not use ADVATE if you are allergic to mice or hamsters or any ingredients in ADVATE.

You should tell your doctor if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines and dietary supplements, have any allergies, including allergies to mice or hamsters, are nursing, are pregnant, or have been told that you have inhibitors to factor VIII.

You could have an allergic reaction to ADVATE. Call your doctor right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, light-headed, dizziness, nausea, or fainting.

Your body may form inhibitors to factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop all factor VIII products including ADVATE from working properly. Consult with your doctor to make sure you are carefully monitored with blood tests to check for the development of inhibitors to factor VIII.

Side effects that have been reported with ADVATE include: cough, sore throat, unusual taste, abdominal pain, diarrhea, nausea, headache, fever, dizziness, hot flashes, chills, sweating, joint swelling, itching, hematoma, and swelling of legs.

Call your doctor right away about any side effects that bother you or if your bleeding does not stop after taking ADVATE.

Please see ADVATE full Prescribing Information (PDF).

After using ADVATE therapy, dispose of the empty vial, reconstitution device, and syringe in a sharps container.

References: 1. Industry, financial, and research reports on file. Westlake Village, CA: Baxter Healthcare Corporation. 2. The National Hemophilia Foundation. MASAC Recommendations Concerning the Treatment of Hemophilia and Other Bleeding Disorders. MASAC Document #190. June 2009. 3. McCormack PL, Plosker GL. Octocog alpha, plasma/albumin-free method. Drugs. 2005;65:2613-2620. 4. ADVATE prescribing information. Westlake Village, CA: Baxter Healthcare Corporation; October 2009. 5. Tarantino MD, Collins PW, Hay CRM, et al, and the rAHF-PFM Clinical Study Group. Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A. Haemophilia. 2004;10:428-437. 6. Shapiro A, Gruppo R, Pabinger I, et al. Integrated analysis of safety and efficacy of a plasma- and albumin-free recombinant factor VIII (rAHF-PFM) from six clinical studies in patients with hemophilia A. Expert Opin Biol Ther. 2009;9(3):273-283. 7. Data on File. Westlake Village, CA: Baxter Healthcare Corporation. 8. World Federation of Hemophilia. Hemophilia—a timeline. Available at: http://www.wfh.org/2/1/1_1_3_Link1_Timeline.htm. Accessed June 7, 2007. 9. RECOMBINATE prescribing information. Westlake Village, CA: Baxter Healthcare Corporation; January 2010. 10. Ewenstein BM, Collins P, Tarantino MD, et al. Hemophilia therapy innovation: development of an advanced category recombinant factor VIII by a plasma/albumin-free method. Semin Hematol. 2004;41(2)(suppl 2):1-18. 11. Blanchette VS, Shapiro AD, Liesner RJ, et al, for the rAHF-PFM Clinical Study Group. Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients. J Thromb Haemost. 2008;6:1319-1326. 12. Négrier C, Shapiro A, Berntorp E, et al. Surgical evaluation of a recombinant factor VIII prepared using a plasma/albumin free method: efficacy and safety of Advate in previously treated patients. Thromb Haemost. 2008;100:217-223. 13. Ewenstein BM, Gomperts ED, Pearson S, O’Banian ME. Inhibitor development in patients receiving recombinant factor VIII (Recombinate rAHF/Bioclate®): a prospective pharmacovigilance study. Haemophilia. 2004;10:491-498. 14. Xyntha prescribing information. Philadelphia, PA: Wyeth Pharmaceuticals Inc; April 2008. 15. Helixate FS prescribing information. Kankakee, IL: CSL Behring LLC; July 2007. 16. Kogenate FS prescribing information. Tarrytown, NY: Bayer Healthcare LLC; October 2008. 17. ReFacto prescribing information. Philadelphia, PA: Wyeth Pharmaceuticals Inc; December 2007. 18. White, GC, DiMichele D, Mertens K, et al. Utilization of previously treated patients (PTPs), noninfected patients (NIPs), and previously untreated patients (PUPs) in the evaluation of new factor VIII and factor IX concentrates. Recommendation of the Scientific Subcommittee of Factor VIII and Factor IX of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost. 1998;81:462